International Journal of Oral and Maxillofacial Surgery
Clinical PaperHead and Neck OncolgogySalivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population☆
Section snippets
Patients and Methods
This study included patients with primary epithelial salivary gland neoplasms who, during the 23-year period between 1985 and 2007, underwent operations in the Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine in the east of China.
Hematoxylin-eosin stained slides (and immunostained sections if necessary) of all cases were reviewed and reclassified by three pathologists based on the World Health Organization (WHO) Pathology
Histological Types
6982 patients underwent operations for salivary gland tumors during the specified period. Of these tumors, 4743 (68%) were benign and 2239 (32%) were malignant. The ratio of benign tumors to malignancies was 2.12:1. The distribution of histological patterns by anatomical locations for benign and malignant salivary tumors are shown in Table 1, Table 2, respectively.
Pleomorphic adenoma (PA) was the most common tumor and accounted for 69% (3281/4743) of all benign tumors, followed by Warthin's
Discussion
Shanghai Ninth People's Hospital is one of the largest comprehensive hospitals in China and is the care center for oral and maxillofacial tumors in the east of China. Many more patients with salivary gland tumors are treated in this hospital than in any other hospital in China. This setting provided an excellent population in which to evaluate the clinicopathological features of these tumors.
The WHO classification of salivary gland tumors, which has had three editions, has been employed in
Funding
Chinese Nature Science Foundation (grant 30672328) and Shanghai Leading Academic Discipline Project (S30206)
Competing Interests
None
Ethical Approval
Not required
Acknowledgement
The authors thank Sunita Patterson from Dept. of Scientific Publications, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA for the English editing of this manuscript.
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This work was supported by Chinese Nature Science Foundation (grant 30672328) and Shanghai Leading Academic Discipline Project (S30206).
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Zhen Tian and Lei Li contributed equally to this work.