Skin and Soft Tissue Infections
Section snippets
Terminology and definitions
A variety of terms are applied to infections of the skin and underlying soft tissue structures. For the purpose of therapeutic clinical trials, the Food and Drug Administration (FDA) uses the term “skin and skin structure infections.”1 The FDA specifically excludes necrotizing deep space infections from clinical trials, however, excluding infections involving the fascial planes and muscle and those infections with the greatest likelihood of adverse outcome.
Additionally, skin and skin structure
Nonnecrotizing skin and soft tissue infections
SSTI may occur with a wide variety of clinical presentations and in numerous clinical settings, with diverse etiologic processes, and with varying severities. Numerous bacteria may be involved in SSTI, with the likelihood of individual pathogens being altered by factors including the inciting disease process and the clinical presentation and setting. Most SSTI infections are generally mild to moderate in severity and include simple cellulitis, folliculitis, furunculosis, and minor
Necrotizing skin and soft tissue infections
NSTI are discussed separately because of (1) the increased severity; (2) the variation of pathogens relative to nonnecrotizing infections; (3) the difficulty and importance of establishing an early diagnosis; and (4) the impact of early, aggressive surgical debridement on outcome. NSTIs are serious infections, producing progressive tissue destruction with significant potential for soft tissue and limb loss and mortality. Despite advances in therapy over the past three decades, the mortality
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No country for old antibiotics! Antimicrobial peptides (AMPs) as next-generation treatment for skin and soft tissue infection
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2023, The Lancet Infectious DiseasesCitation Excerpt :Necrotising soft-tissue infections are life-threatening infections characterised by subcutaneous tissue, fascia, or muscle necrosis, associated with high morbidity and mortality.1 Early diagnosis is a challenge, with more than half of patients initially misdiagnosed.2,3 Despite their relative low incidence, most physicians might see one case of necrotising soft-tissue infection throughout their career and should be aware of this condition.
Necrotizing Soft-Tissue Infections After Hip Arthroplasty
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2019, Journal of Emergency MedicineReliability of the Laboratory Risk Indicator in Necrotising Fasciitis (LRINEC) score
2019, SurgeonCitation Excerpt :The information provided by the case reports as regards the association between NF and LRINEC score is relevant to clinical practice and support other evidence. May (2009)4 carried out a literature review discussing the diagnosis and management of complicated skin and soft tissue infections (SSTI) and necrotising soft tissue infections (NSTI). This is a comprehensive review article addressing all aspects of necrotising infections and summarises the available literature with references.
Assessing Second Debridement Timing and Mortality in Necrotizing Soft Tissue Infections
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