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Prospective Observational Study to Establish Predictors of Glyburide Success in Women with Gestational Diabetes Mellitus

Journal of Perinatology volume 24, pages 617–622 (2004)Cite this article

Abstract

OBJECTIVE: To establish parameters associated with therapeutic success in gestational diabetics treated with glyburide.

STUDY DESIGN: A total of 69 gestational diabetics who failed dietary therapy were treated with glyburide. Inadequate glycemic control on maximum dose glyburide (10 mg b.i.d.) was considered treatment failure. The glyburide failure rate was calculated and factors that might predict success with glyburide were analyzed between the success and failure groups using χ2 or Student'st-tests.

RESULTS: The glyburide failure rate was 18.8%. Gestational age at glyburide initiation (p<0.01), pretreatment fasting blood sugars (p<0.001), and 1-hour postprandial values (p<0.001) were the only statistically significant factors between the two groups. Glyburide success was predicted if dietary failure occurred after 30 weeks, or fasting blood sugars were <110 mg/dl and 1-hour postprandials were <140 mg/dl (sensitivity 98%, specificity 65%).

CONCLUSION: Gestational diabetics who fail dietary therapy after 30 weeks gestation or have fasting blood sugars <110 mg/dl and 1-hour postprandials <140 mg/dl do well on glyburide therapy.

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Authors and Affiliations

  1. Division of Reproductive Medicine, University of California, San Diego, CA, USA

    Ramen Chmait MD

  2. School of Medicine, University of California, San Diego, CA, USA

    Theresa Dinise BS

  3. Division of Reproductive Medicine, University of California, San Diego, CA, USA

    Thomas Moore MD

Authors
  1. Ramen Chmait MD
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  2. Theresa Dinise BS
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  3. Thomas Moore MD
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Chmait, R., Dinise, T. & Moore, T. Prospective Observational Study to Establish Predictors of Glyburide Success in Women with Gestational Diabetes Mellitus. J Perinatol 24, 617–622 (2004). https://doi.org/10.1038/sj.jp.7211147

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  • DOI: https://doi.org/10.1038/sj.jp.7211147

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