Regular ArticleAssessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis
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ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors)
2018, Clinical Microbiology and InfectionCitation Excerpt :Indeed, IL1-β production has been demonstrated in lung granulomas from patients with active pulmonary TB, as well as an increased ratio of IL-1β to IL-1R. Certain single nucleotide polymorphisms in the IL1B gene may influence risk of extrapulmonary TB in the general population [19,20] or invasive fungal infection in solid organ transplant recipients [21]. Short-course therapy with IL-1 inhibitors (anakinra, canakinumab or rilonacept) for acute flares of gouty arthritis are usually well tolerated in the setting of RCTs, with no significant increase in the incidence of infectious events [22–24].
Association of TNF-α IL-10 and IL-6 promoter polymorphisms in pulmonary tuberculosis patients and their household contacts of younger age group
2018, Comparative Immunology, Microbiology and Infectious DiseasesImpaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals
2018, TuberculosisCitation Excerpt :IL-1β is essential for the host control of this bacterial infection, demonstrated by the significantly impaired survival of IL-1β knockout (KO) and IL-1R KO mice infected with M. tuberculosis [5,6]. Furthermore, polymorphisms in the IL1 gene cluster also predispose individuals to TB [7,8]. The IL-17 is also involved in the TB control, by recruiting neutrophils, although it may contribute to tissue damage in advanced TB [9,10].
IL-1β +3953C/T, -511T/C and IL-6 -174C/G polymorphisms in association with tuberculosis susceptibility: A meta-analysis
2015, GeneCitation Excerpt :In the stratified analysis by ethnicity, we observed significantly decreased TB risk associated with the IL-1β − 511T/C polymorphism in Africans under allele model and homozygous model, which is in consistency with the research conducted by Awomoyi et al. In view of the relatively small sample size of people (two studies) were included in the pooling analysis of African subgroup (Bellamy et al., 1998; Awomoyi et al., 2005), additional large studies are warranted to validate this finding. Meanwhile, a decreased TB risk associated with IL-6 − 174C/G polymorphism was found under allele model, heterozygous model and dominant model in Asians, respectively.