ORIGINAL ARTICLES
ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)

https://doi.org/10.1111/j.1538-7836.2007.02579.xGet rights and content
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Summary

Background: Numerous case–control studies have reported higher prevalence of non‐O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established. Patients/methods: Using a nested case–control design combining the Atherosclerosis Risk in Communities and the Cardiovascular Health Study cohort, ABO blood type and other VTE risk factors were measured on pre‐event blood samples of 492 participants who subsequently developed VTE and 1008 participants who remained free of VTE. Results: A total of 64.4% of cases and 52.5% of controls had non‐O blood type. Among controls, mean values of factor VIIIc (FVIIIc) and von Willebrand factor among the non‐O blood type group were higher than among the O group. Compared with O blood type, the age‐adjusted odds ratio (OR) of VTE for non‐O blood type was 1.64 (95% CI, 1.32–2.05) and was similar for the two parent studies and race groups. Further adjustment for sex, race, body mass index, diabetes mellitus and FVIIIc reduced the OR: 1.31 (95% CI, 1.02–1.68). Factor V Leiden (FV Leiden) appeared to modify the non‐O blood type association with VTE in a supra‐additive fashion, with an age‐, sex‐ and race‐adjusted OR of 6.77 (95% CI, 3.65–12.6) for having both risk factors. Conclusions: Non‐O blood type was independently associated with risk of VTE, and added to the risk associated with FV Leiden.

Keywords

blood type
coagulation factor
epidemiology
risk factors
venous thrombosis

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