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Distributions of Angiogenesis and Lymphangiogenesis in Gastrointestinal Intramucosal Tumors

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Although angiogenesis and lymphangiogenesis in gastrointestinal cancers has been investigated in many studies, their distribution characteristics in gastrointestinal intramucosal tumors have not been well addressed.

Methods

We evaluated the blood microvessel density (BMVD) and lymphatic microvessel density (LMVD) by immunostaining with monoclonal antibodies of CD34 and D2-40 in 37 patients with stomach intramucosal carcinoma and 28 patients with colorectal intramucosal neoplasia. Microvessels with endothelial cells labeled by CD34 but not by D2-40 were recognized as blood microvessels; and microvessels with endothelial cells labeled by both CD34 and D2-40 were recognized as lymphatic vessels. Furthermore, the relationships between expression of vascular endothelial growth factor (VEGF), VEGF-C, and BMVD, LMVD were investigated as well.

Results

The LMVD was significantly higher in peritumoral tissues than in corresponding normal tissues in gastrointestinal intramucosal tumors (20.87 versus 14.56, P = 0.003). However, there was no significant difference in the BMVD between peritumoral tissues and corresponding normal tissues (P = 0.166). The BMVD in peritumoral tissues was higher in patients with lymph node metastases than in patients without lymph nodes metastases (P = 0.047). Our results did not show significant association between VEGF, VEGF-C and BMVD, LMVD.

Conclusions

Our results suggested that the increase of lymphangiogenesis seems superior to the increase of angiogenesis in gastrointestinal intramucosal tumors.

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Acknowledgments

We thank the editors and reviewers who revised the paper. Special thanks are due to Dr. Jing-jing Lu for her statistical advice. The authors would like to thank Mrs. Hong Han for her excellent assistance.

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Authors and Affiliations

  1. Department of Pathology, Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, P. R. China

    Yan Gao MD, MS, Wei-Xia Zhong MD, Dian-Bin Mu MD, Yin-Ping Yuan MD, MS, Lan-Ping Sun, Yu-Hui Li MD, Jian-Bo Zhang MD, Yan Zhao & Shu-Ping Cai MD

  2. Department of Pathology, School of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, 250012, Shandong, P. R. China

    Yan Gao MD, MS, Yu-Hua Zhang MD, PhD & Geng-Yin Zhou MD, MS

  3. The Center Laboratory of Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, P. R. China

    Jin-Ming Yu MD, PhD

  4. Breast Cancer Center, Shandong Cancer Hospital, Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, Shandong, P. R. China

    Lei Wang MD, PhD

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  1. Yan Gao MD, MS
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  13. Geng-Yin Zhou MD, MS
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Correspondence to Geng-Yin Zhou MD, MS.

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Gao, Y., Zhong, WX., Mu, DB. et al. Distributions of Angiogenesis and Lymphangiogenesis in Gastrointestinal Intramucosal Tumors. Ann Surg Oncol 15, 1117–1123 (2008). https://doi.org/10.1245/s10434-007-9752-6

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  • DOI: https://doi.org/10.1245/s10434-007-9752-6

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