Skip to main content

Advertisement

SpringerLink
Log in

Association of Thyroid, Breast and Renal Cell Cancer: A Population-based Study of the Prevalence of Second Malignancies

  • Endocrine Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Analysis of the National Cancer Institute’s Surveillance, Epidemiology, and End Results data has shown that the incidence of thyroid cancer is higher in patients with a preexisting malignancy and that the incidence of other malignancies is higher in patients with thyroid cancer. The purpose of this study was to evaluate the prevalence of a second malignancy in patients treated for thyroid, breast or renal cell cancer and determine what associations, if any, exist between these cancers.

Methods

This study utilized the novel data system, Explorys, as its population base. Patient cohorts were constructed using ICD-9 codes, and prevalence rates were obtained for each cancer. Rates of second malignancy were obtained and compared to the baseline prevalence for a particular malignancy.

Results

Female thyroid cancer patients had a 0.67- and twofold increase in prevalence of a subsequent breast and renal cell cancer. Female breast and renal cell cancer patients had a twofold and 1.5-fold increase in the prevalence of thyroid cancer, respectively. Male patients with thyroid cancer had a 29- and 4.5-fold increase in prevalence of subsequent breast and renal cell cancer. Male patients with breast and renal cell cancer had an increased prevalence of subsequent thyroid cancer, 19- and threefold, respectively.

Conclusions

Our study demonstrated a bidirectional association between thyroid, breast and renal cancer in both male and female patients. This may have important implications for patient follow-up and screening after treatment of a primary cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975–2009. Vintage 2009 populations, based on November 2011 SEER data submission. http://seer.cancer.gov/csr/1975_2009_pops09/. Accessed 3 Apr 2012.

  2. Canchola AJ, Horn-Ross PL, Purdie DM. Risk of second primary malignancies in women with papillary thyroid cancer. Am J Epidemiol. 2006;163:521–7.

    Article  PubMed  Google Scholar 

  3. Siegal R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011. CA Cancer J Clin. 2011;61:212–36.

    Article  Google Scholar 

  4. Ronckers CM, McCarron P, Engels EA, Ron E. New malignancies following cancer of the thyroid and other endocrine glands. In: Curtis RE, Freedman DM, Ron E, et al., editors. New malignancies among cancer survivors: SEER cancer registries, 1973–2000. NIH Publication 05-5302. Bethesda, MD: National Cancer Institute; 2006. p. 375–95.

  5. Lee K, Chen S, Chan CH, et al. Increased risk for second primary malignancies in women with breast cancer diagnosed at young age: a population-based study in Taiwan. Cancer Epidemiol Biomarkers Prev. 2008;17:2647–60.

    Article  PubMed  Google Scholar 

  6. Brown AP, Chen J, Hitchcock YJ, Szabo A, Shrueve, DC, Tward JD. The risk of second primary malignancies up to three decades after the treatment of differentiated thyroid cancer. J Clin Endocrinol Metab. 2008;93:504–15.

    Article  PubMed  CAS  Google Scholar 

  7. Garner CN, Ganetzky R, Brainard J, et al. Increased Prevalence of breast cancer among patients with thyroid and parathyroid disease. Surgery. 2007;142:806–13.

    Article  PubMed  Google Scholar 

  8. Verkooijen RBT, Smit JWA, Romijn JA, Stokkel MPM. The Incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer. Eur J Endocrinol. 2006;155:801–6.

    Article  PubMed  CAS  Google Scholar 

  9. Raymond JS, Hogue CJR. Multiple primary tumours in women following breast cancer, 1973–2000. Br J Cancer. 2006;94:1745–50.

    PubMed  CAS  Google Scholar 

  10. Yu GY, Schantz SP, Neugut AI, Zhang ZF. Incidences and trends of second cancers in female breast cancer patients: a fixed inception cohort-based analysis (United States). Cancer Causes Control. 2006;17:411–20.

    Article  PubMed  Google Scholar 

  11. Sandeep TC, Strachan MW, Reynolds RM, et al. Second primary cancers in thyroid cancer patients: a multinational record linkage study. J Clin Endocrinol Metab. 2006;91:1819–25.

    Article  PubMed  CAS  Google Scholar 

  12. Ronckers CM, McCarron P, Ron E. Thyroid cancer and multiple primary tumors in the SEER cancer registries. Int J Cancer. 2005;117:281–8.

    Article  PubMed  CAS  Google Scholar 

  13. Berthe E, Henry-Amar M, Michels J, et al. Risk of second primary cancer following differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 2004;31:685–91.

    Article  PubMed  Google Scholar 

  14. Chen AY, Levy L, Goepfert H, Brown BW, Spitz MR, Vassilopoulou-Sellin R. The development of breast carcinoma in women with thyroid carcinoma. Cancer. 2001;92:225–31.

    Article  PubMed  CAS  Google Scholar 

  15. Vassilopoulou-Sellin R, Palmer L, Taylor S, Cooksley CS. Incidence of breast carcinoma in women with thyroid carcinoma. Cancer. 1998;85:696–705.

    Article  Google Scholar 

  16. Li CI, Rossing MA, Voigt LF, Daling JR. Multiple primary breast and thyroid cancers: role of age at diagnosis and cancer treatments (United States). Cancer Causes Control. 2000;11:805–11.

    Article  PubMed  CAS  Google Scholar 

  17. McTiernan A, Weiss NS, Daling JR. Incidence of thyroid cancer in women in relation to known or suspected risk factors for breast cancer. Cancer Res. 1987;47:292–5.

    PubMed  CAS  Google Scholar 

  18. Chalstrey LJ, Benjamin B. High incidence of breast cancer in thyroid cancer patients. Br J Cancer. 1966;20:670–5.

    Article  PubMed  CAS  Google Scholar 

  19. Simon MS, Tang MTC, Bernstein L, et al. Do thyroid disorders increase the risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2002;11:1574–8.

    PubMed  Google Scholar 

  20. Rubino C, deVathaire F, Dottorini ME, et al. Second Primary malignancies in thyroid cancer patients. Br J Cancer. 2003;89:1638–44.

    Article  PubMed  CAS  Google Scholar 

  21. Adjadj E, Rubino C, Shamsaldim A, Le MG, Schlumberger M, de Vathaire F. The risk of multiple primary breast and thyroid carcinomas: role of the radiation dose. Cancer. 2003;98:1309–17.

    Article  PubMed  Google Scholar 

  22. Sadetzki S, Calderon-Margalit R, Peretz C, Novikov I, Barchana M, Papa MZ. Second Primary breast and thyroid cancers (Israel). Cancer Causes Control. 2003;14:367–75.

    Article  PubMed  Google Scholar 

  23. Ron E, Curtis R, Hoffman DA, Flannery JT. Multiple primary and thyroid cancer. Br J Cancer. 1984;49:87–92.

    Article  PubMed  CAS  Google Scholar 

  24. Curtis RE, Ron E, Jankey BF, Hoover RN. New malignancies following breast cancer. In: Curtis RE, Freedman DM, Ron E, et al., editors. New malignancies among cancer survivors: SEER cancer registries, 1973–2000. NIH Publication 05-5302. Bethesda, MD: National Cancer Institute; 2006. pp. 181–205.

  25. Lal G, Groff M, Howe JR, Weigel RJ, Sugg SL, Lynch CF. Risk of subsequent primary thyroid cancer after another malignancy: latency trends in a population-based study. Ann Surg Oncol. 2012;19:1887–96.

    Article  PubMed  Google Scholar 

  26. Wilson RT, Silverman DT, Fraumeni JF, Curtis RE. New malignancies following cancer of the urinary tract. In: Curtis RE, Freeman DM, Ron E, et al., editors. New malignancies among cancer survivors: SEER cancer registries, 1973–2000. NIH Publication 05-5302. Bethesda, MD: National Cancer Institute; 2006. p. 285–312.

  27. Gilder JR. Big data in healthcare: the next frontier in clinical research, study trial recruitment, and quality assessment. Monitor. 2012(April):55–8.

Download references

Acknowledgment

We would like to thank the Explorys team for their expertise: Anil Jain, MD, Jason Gilder, PhD, Wendy Foster, MPH, RHIA and Sarah Mihalik, Heather Holmes, Clinical Informationalist, Summa Health System, and Steve Getch, Corporate Communications, Summa Health System.

Author information

Authors and Affiliations

  1. Department of Surgery, Summa Health System, Akron City Hospital, Akron, OH, USA

    Victoria L. Van Fossen MD

  2. Department of Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA

    Scott M. Wilhelm MD

  3. Department of Research Administration Summa Health System, Akron City Hospital, Akron, OH, USA

    Jennifer L. Eaton Ph.D

  4. Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA

    Christopher R. McHenry MD

  5. NEOMED, Rootstown, OH, USA

    Victoria L. Van Fossen MD

Authors
  1. Victoria L. Van Fossen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott M. Wilhelm MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jennifer L. Eaton Ph.D
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christopher R. McHenry MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Victoria L. Van Fossen MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Van Fossen, V.L., Wilhelm, S.M., Eaton, J.L. et al. Association of Thyroid, Breast and Renal Cell Cancer: A Population-based Study of the Prevalence of Second Malignancies. Ann Surg Oncol 20, 1341–1347 (2013). https://doi.org/10.1245/s10434-012-2718-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-012-2718-3

Keywords

Search

Navigation