A 57 year-old-man developed a left ophthalmoplegia associated with ataxia and areflexia while he had fever (39 degrees C) for two days. Dengue fever (DF) was diagnosed by definite criteria, i.e.: IgM seroconversion, positive culture from serum and positive PCR both from serum and CSF. Within one week, he fully and spontaneously recovered. To our knowledge, this neurological picture has never been reported in DF. Considering the immune-mediated nature of this condition, its pathogenesis in DF is proposed in reviewing the literature.