Abstract
The incidence of drug resistance in Mycobacterium tuberculosis (MTB) isolated from our hospital between April 1996 and March 1998 was compared with an earlier study (1993-1995). Thirty (29.7%) of 101 MTB isolates were resistant to one or more anti-TB drugs and 21 (20%) of 101 were multi-drug resistant M. tuberculosis (MDR-TB). Resistance was most common to isoniazid (28.7%), followed by streptomycin (22.8%) and rifampicin (20.8%). Resistance to pyrazinamide and ethambutol was 7.9 and 6.9%, respectively. There was a three-fold increase in resistance compared with the earlier study.
MeSH terms
-
Antitubercular Agents / pharmacology
-
Antitubercular Agents / therapeutic use*
-
Drug Resistance, Microbial
-
Ethambutol / pharmacology
-
Ethambutol / therapeutic use
-
Female
-
Humans
-
Isoniazid / pharmacology
-
Isoniazid / therapeutic use
-
Male
-
Microbial Sensitivity Tests
-
Mycobacterium tuberculosis / drug effects*
-
Mycobacterium tuberculosis / isolation & purification
-
Prevalence
-
Pyrazinamide / pharmacology
-
Pyrazinamide / therapeutic use
-
Rifampin / pharmacology
-
Rifampin / therapeutic use
-
Saudi Arabia / epidemiology
-
Streptomycin / pharmacology
-
Streptomycin / therapeutic use
-
Tuberculosis / drug therapy*
-
Tuberculosis / epidemiology
-
Tuberculosis / microbiology
-
Tuberculosis, Multidrug-Resistant / drug therapy
-
Tuberculosis, Multidrug-Resistant / epidemiology
-
Tuberculosis, Multidrug-Resistant / microbiology
-
Tuberculosis, Pulmonary / drug therapy
-
Tuberculosis, Pulmonary / epidemiology
-
Tuberculosis, Pulmonary / microbiology
Substances
-
Antitubercular Agents
-
Pyrazinamide
-
Ethambutol
-
Isoniazid
-
Rifampin
-
Streptomycin