Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects

Evert de Jonge; Philip W Friederich; George P Vlasuk; William E Rote; Margaretha B Vroom; Marcel Levi; Tom van der Poll

doi:10.1128/cdli.10.3.495-497.2003

Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects

Clin Diagn Lab Immunol. 2003 May;10(3):495-7. doi: 10.1128/cdli.10.3.495-497.2003.

Authors

Evert de Jonge¹, Philip W Friederich, George P Vlasuk, William E Rote, Margaretha B Vroom, Marcel Levi, Tom van der Poll

Affiliation

¹ Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands. e.dejonge@amc.uva.nl

Abstract

The activation of coagulation has been shown to contribute to proinflammatory responses in animal and in vitro experiments. Here we report that the activation of coagulation in healthy human subjects by the administration of recombinant factor VIIa also elicits a small but significant increase in the concentrations of interleukin 6 (IL-6) and IL-8 in plasma. This increase was absent when the subjects were pretreated with recombinant nematode anticoagulant protein c2, the inhibitor of tissue factor-factor VIIa.

MeSH terms

Blood Coagulation / drug effects*
Factor VII / administration & dosage
Factor VII / antagonists & inhibitors
Factor VII / pharmacology*
Factor VIIa
Helminth Proteins / pharmacology
Humans
Interleukin-6 / blood
Interleukin-8 / blood
Kinetics
Recombinant Proteins / administration & dosage
Recombinant Proteins / antagonists & inhibitors
Recombinant Proteins / pharmacology*

Substances

Helminth Proteins
Interleukin-6
Interleukin-8
Recombinant Proteins
anti-coagulant protein C2, Ancylostoma caninum
Factor VII
recombinant FVIIa
Factor VIIa