The purpose of this study was to establish tooth width and arch dimensions in normal and malocclusion samples and to compare tooth width and arch dimensions between males and females in normal and malocclusion samples. A total of 120 pairs of orthodontic study casts were included in the study. An electronic digital caliper was used for the measurements. Descriptive statistics and the t-test were used for the statistical analysis of the data. Tooth width and arch dimensions were established in normal and malocclusion in the present study. Significant differences were found in tooth width between normal and malocclusion samples. However, no significant difference was observed in arch dimensions. Furthermore, there was statistical significant difference in tooth width between males and females where the males showed higher mean values. The same was true when arch dimensions were compared. The results of the current investigation are of great value to the anthropologist as well as to the orthodontist in understanding dimensional arch criteria and orthodontic arch wire selection. Furthermore, it helps the prosthodontist in the selection of the correct shape and size of stock impression trays and of suitable molds of artificial teeth for fixed and removable prostheses.