Abstract
Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Hypoxia / radiation effects*
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Gene Expression Regulation, Neoplastic / radiation effects
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Humans
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Hypoxia-Inducible Factor 1 / genetics
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Hypoxia-Inducible Factor 1 / physiology*
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplasms / radiotherapy*
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Radiation Tolerance*
Substances
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Hypoxia-Inducible Factor 1