Abstract
Objective:
To review the clinical features and outcome of all cases of stage 4S neuroblastoma treated at our center.
Methods:
We retrospectively reviewed the files of all patients (n=75) with neuroblastoma treated at King Abdul-Aziz Medical City, Jeddah, Kingdom of Saudi Arabia between 1986 and 2005. We studied the clinical features and outcome of patients with stage 4S neuroblastoma.
Results:
Six patients (8%) were confirmed to have stage 4S neuroblastoma. Three were boys with a median age at diagnosis of 4.5 months (range 28 days-11 months). Four patients required no intervention. The remaining 2 patients were treated with chemotherapy due to progressive hepatomegaly and respiratory distress. No patient required radiotherapy or surgical intervention. With a median follow up of 4 years (range 9 months-15.5 years), all patients are alive and well. Two patients continue to have a residual abdominal mass, while complete resolution occurred in the others.
Conclusion:
Stage 4S neuroblastoma is a special tumor that carries excellent prognosis. Spontaneous regression may occur and intervention is only required in symptomatic patients.
MeSH terms
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Adrenal Gland Neoplasms* / diagnosis
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Adrenal Gland Neoplasms* / diagnostic imaging
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Adrenal Gland Neoplasms* / drug therapy
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Adrenal Gland Neoplasms* / pathology
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Adrenal Glands / pathology
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Age Factors
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents, Alkylating / administration & dosage
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Antineoplastic Agents, Alkylating / therapeutic use
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biopsy
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Carboplatin / administration & dosage
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Carboplatin / therapeutic use
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Etoposide / administration & dosage
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Etoposide / therapeutic use
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Female
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Follow-Up Studies
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Hepatomegaly / diagnosis
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Hepatomegaly / etiology
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Humans
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Infant
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Infant, Newborn
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Liver Neoplasms* / diagnosis
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Liver Neoplasms* / diagnostic imaging
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Liver Neoplasms* / drug therapy
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Liver Neoplasms* / pathology
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Male
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Neoplasm Regression, Spontaneous
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Neoplasm Staging
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Neuroblastoma* / diagnosis
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Neuroblastoma* / diagnostic imaging
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Neuroblastoma* / drug therapy
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Neuroblastoma* / mortality
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Neuroblastoma* / pathology
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Neuroblastoma* / secondary
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Prognosis
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Retrospective Studies
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Saudi Arabia
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Skin / pathology
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Skin Neoplasms / diagnosis
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Skin Neoplasms / pathology
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Skin Neoplasms / secondary
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Survival Analysis
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Time Factors
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Tomography, X-Ray Computed
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Treatment Outcome
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Vincristine / administration & dosage
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Vincristine / therapeutic use
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Alkylating
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Antineoplastic Agents, Phytogenic
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Carboplatin