Abstract
A phytochemical investigation of stems from Salvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide, N1,N4-bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1), N-benzyl-2-phenylacetamide (2), N-benzylbenzamide (3) and benzylurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound 2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate antibacterial activity against Escherichia coli.
MeSH terms
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Amides / chemistry*
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Anti-Bacterial Agents / pharmacology
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Benzyl Compounds / chemistry*
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Collagen / antagonists & inhibitors
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Collagen / pharmacology
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Escherichia coli / drug effects
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Humans
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In Vitro Techniques
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Plant Stems / chemistry
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / pharmacology
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Salvadoraceae / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Amides
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Anti-Bacterial Agents
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Benzyl Compounds
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Indicators and Reagents
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Platelet Aggregation Inhibitors
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Collagen