Efficacy of 1% ropivacaine gel for topical anesthesia of human oral mucosa

Quintessence Int. 2007 Jul-Aug;38(7):601-6.

Abstract

Objective: To evaluate the efficacy of 1% ropivacaine for topical anesthesia in dentistry.

Method and materials: Thirty healthy volunteers randomly (blind crossover) received the following treatments: 20 mg of 1% ropivacaine gel (ropivacaine-20), 60 mg of 1% ropivacaine gel (ropivacaine-60), 20 mg of the eutectic mixture of local anesthetics 2.5% lidocaine and 2.5% prilocaine (EMLA cream, AstraZeneca; EMLA-20), 60 mg of EMLA (EMLA-60), 20 mg of 20% benzocaine gel (Benzotop, DFL; benzocaine-20), and 60 mg of 20% benzocaine gel (benzocaine-60), applied on the maxillary buccal fold of the right canine at different sessions. Pain was assessed by visual analog scale (VAS) and 11-point box scale (BS-11) after the insertion of 30-gauge needles. Soft tissue anesthesia was measured by pinprick test. Data were analyzed by Friedman and Pearson correlation tests.

Results: All the topical anesthetics evaluated showed similar performance in relation to the pain perceived after needle insertion (P >.05), and there were no significant differences among groups considering VAS or BS-11 (P = .177 and P = .179, respectively). The duration of soft tissue anesthesia was not statistically significantly different for ropivacaine-20, EMLA-20, benzocaine-20, ropivacaine-60, EMLA-60, and benzocaine-60, but EMLA-60 showed significantly longer duration than the other agents (P <.05).

Conclusion: All topical anesthetics were similar in reducing pain to needle insertion. EMLA-60 promoted longer duration of soft tissue anesthesia.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Amides / administration & dosage*
  • Anesthesia, Dental / methods*
  • Anesthesia, Local / methods
  • Anesthetics, Local / administration & dosage*
  • Benzocaine / administration & dosage
  • Cross-Over Studies
  • Double-Blind Method
  • Facial Pain / etiology
  • Facial Pain / prevention & control*
  • Female
  • Gels
  • Humans
  • Injections / adverse effects
  • Lidocaine / administration & dosage
  • Lidocaine, Prilocaine Drug Combination
  • Male
  • Mouth Mucosa
  • Pain Measurement
  • Prilocaine / administration & dosage
  • Ropivacaine

Substances

  • Amides
  • Anesthetics, Local
  • Gels
  • Lidocaine, Prilocaine Drug Combination
  • Prilocaine
  • Ropivacaine
  • Lidocaine
  • Benzocaine