Abstract
The current study examined whether modafinil would reinstate an extinguished cocaine conditioned place preference (CPP). Following extinction of a cocaine CPP, rats were administered modafinil (128 mg/kg), cocaine (5 mg/kg) or vehicle and given a 60-min reinstatement test. While the effect of cocaine was transient, modafinil robustly reinstated a cocaine CPP following extinction, suggesting that modafinil may induce relapse or increase the vulnerability of addicts to the reinforcing effects of environmental triggers.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Analysis of Variance
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Animals
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Benzhydryl Compounds / pharmacology*
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Central Nervous System Stimulants / pharmacology*
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Cocaine / pharmacology*
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Conditioning, Classical / drug effects*
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Dopamine Uptake Inhibitors / pharmacology*
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Environment
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Extinction, Psychological / drug effects*
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Male
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Modafinil
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Motor Activity / drug effects
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Random Allocation
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Rats
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Rats, Sprague-Dawley
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Space Perception / drug effects
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Time Factors
Substances
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Benzhydryl Compounds
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Central Nervous System Stimulants
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Dopamine Uptake Inhibitors
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Cocaine
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Modafinil