Abstract
Nesfatin-1 is recently reported as a satiety molecule to suppress food intake via the melanocortin signaling in hypothalamus when injected centrally and peripherally. Here we report that nesfatin-1 is also anti-hyperglycemic. It was found that the intravenous injection of nesfatin-1 significantly reduced blood glucose in hyperglycemic db/db mice. This anti-hyperglycemic effect of nesfatin-1 was time-, dose-, insulin-dependent and peripheral.
Copyright 2009 Elsevier Inc. All rights reserved.
MeSH terms
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Anilides / pharmacology
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Animals
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Appetite Depressants / pharmacology*
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Blood Glucose / drug effects*
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Calcium-Binding Proteins
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DNA-Binding Proteins
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Eating / drug effects
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Hyperglycemia / metabolism*
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Hypolipidemic Agents / pharmacology*
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Insulin / metabolism
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Mice
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Mice, Mutant Strains
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Nerve Tissue Proteins
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Nucleobindins
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Peptide Hormones / biosynthesis
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Peptide Hormones / genetics
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Peptide Hormones / pharmacology*
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Pyrazoles / pharmacology
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Pyrimidines / pharmacology
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Receptors, Leptin / genetics
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Rosiglitazone
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Thiazolidinediones / pharmacology
Substances
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2-chloro-5-nitrobenzanilide
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Anilides
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Appetite Depressants
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Blood Glucose
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Calcium-Binding Proteins
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DNA-Binding Proteins
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Hypolipidemic Agents
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Insulin
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Nerve Tissue Proteins
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Nucb1 protein, mouse
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Nucleobindins
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Peptide Hormones
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Pyrazoles
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Pyrimidines
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Receptors, Leptin
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Thiazolidinediones
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leptin receptor, mouse
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Rosiglitazone
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dorsomorphin