Visceral leishmaniasis (kala-azar) and malaria coinfection in an immigrant in the state of Terengganu, Malaysia: A case report

J Microbiol Immunol Infect. 2011 Feb;44(1):72-6. doi: 10.1016/j.jmii.2011.01.014. Epub 2011 Jan 13.

Abstract

Malaria is endemic in Malaysia. Leishmaniasis is a protozoan infection rarely reported in Malaysia. Here, a 24-year-old Nepalese man who presented with prolonged fever and hepatosplenomegaly is reported. Blood film examination confirmed a Plasmodium vivax malaria infection. Despite being adequately treated for malaria, his fever persisted. Bone marrow examination showed presence of Leishman-Donovan complex. He was successfully treated with prolonged course of amphotericin B. The case highlights the importance of awareness among the treating physicians of this disease occurring in a foreign national from an endemic region when he presents with fever and hepatosplenomegaly. Coinfection with malaria can occur although it is rare. It can cause significant delay of the diagnosis of leishmaniasis.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Antiprotozoal Agents / therapeutic use
  • Bone Marrow / pathology
  • Coinfection / diagnosis*
  • Coinfection / pathology*
  • Emigrants and Immigrants*
  • Humans
  • Leishmaniasis, Visceral / complications*
  • Leishmaniasis, Visceral / diagnosis*
  • Leishmaniasis, Visceral / pathology
  • Malaria, Vivax / complications*
  • Malaria, Vivax / diagnosis*
  • Malaria, Vivax / pathology
  • Malaysia
  • Male
  • Treatment Outcome
  • Young Adult

Substances

  • Antiprotozoal Agents
  • Amphotericin B