Neuromuscular blocking agents for electroconvulsive therapy: a systematic review

Acta Anaesthesiol Scand. 2012 Jan;56(1):3-16. doi: 10.1111/j.1399-6576.2011.02520.x. Epub 2011 Sep 26.

Abstract

Electroconvulsive therapy (ECT) is the transcutaneous application of small electrical stimuli to the brain to induce generalised seizures for the treatment of selected psychiatric disorders. The clinical indications for ECT as an effective therapeutic modality have been considerably expanded since its introduction. Anaesthesia and neuromuscular blocking agents (NMBAs) are required to ensure patients' safety during ECT. The optimal dose of muscle relaxant for ECT reduces muscle contractions without inducing complete paralysis. Slight residual motor convulsive activity is helpful in ascertaining that a seizure has occurred, while total paralysis prolongs the procedure unnecessarily. Suxamethonium is commonly used, but nondepolarising NMBAs are indicated in patients with certain comorbidities. In this review, we summarise current concepts of NMBA management for ECT.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Androstanols
  • Atracurium / analogs & derivatives
  • Convulsants / therapeutic use
  • Depressive Disorder / therapy
  • Electroconvulsive Therapy / adverse effects
  • Electroconvulsive Therapy / methods*
  • Humans
  • Isoquinolines
  • Mivacurium
  • Monitoring, Physiologic
  • Neuromuscular Blocking Agents* / adverse effects
  • Neuromuscular Blocking Agents* / antagonists & inhibitors
  • Neuromuscular Depolarizing Agents
  • Neuromuscular Nondepolarizing Agents
  • Rocuronium
  • Seizures / complications
  • Seizures / physiopathology
  • Succinylcholine
  • Sugammadex
  • Vecuronium Bromide
  • gamma-Cyclodextrins / therapeutic use

Substances

  • Androstanols
  • Convulsants
  • Isoquinolines
  • Neuromuscular Blocking Agents
  • Neuromuscular Depolarizing Agents
  • Neuromuscular Nondepolarizing Agents
  • gamma-Cyclodextrins
  • Atracurium
  • Sugammadex
  • Mivacurium
  • Vecuronium Bromide
  • Succinylcholine
  • cisatracurium
  • Rocuronium