Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals

Katherine W Kooij; Ferdinand W N M Wit; Thijs Booiman; Marc van der Valk; Maarten F Schim van der Loeff; Neeltje A Kootstra; Peter Reiss; AGEhIV Cohort Study Group

doi:10.1093/infdis/jiw459

Cigarette Smoking and Inflammation, Monocyte Activation, and Coagulation in HIV-Infected Individuals Receiving Antiretroviral Therapy, Compared With Uninfected Individuals

J Infect Dis. 2016 Dec 15;214(12):1817-1821. doi: 10.1093/infdis/jiw459. Epub 2016 Sep 28.

Authors

Katherine W Kooij^{1

2}, Ferdinand W N M Wit^{1

3

4

2

5}, Thijs Booiman^{1

6

2}, Marc van der Valk^{3

4}, Maarten F Schim van der Loeff^{3

4

7}, Neeltje A Kootstra⁶, Peter Reiss^{1

3

4

2

5}; AGEhIV Cohort Study Group

Collaborators

AGEhIV Cohort Study Group:
P Reiss, F W N M Wit, M van der Valk, J Schouten, K W Kooij, R A van Zoest, E Verheij, B C Elsenga, M Prins, M F Schim van der Loeff, M Martens, S Moll, J Berkel, M Totté, G R Visser, L May, S Kovalev, A Newsum, M Dijkstra, S Zaheri, M M J Hillebregt, Y M C Ruijs, D P Benschop, A El Berkaoui, W Zikkenheiner, F R Janssen, N A Kootstra, A M Harskamp-Holwerda, I Maurer, T Booiman, M M Mangas Ruiz, A F Girigorie, B Boeser-Nunnink, S E Geerlings, M H Godfried, A Goorhuis, J W R Hovius, J T M van der Meer, F J B Nellen, T van der Poll, J M Prins, P Reiss, M van der Valk, W J Wiersinga, M van Vugt, G de Bree, F W N M Wit, J van Eden, A M H van Hes, M Mutschelknauss, H E Nobel, F J J Pijnappel, M Bijsterveld, A Weijsenfeld, S Smalhout, J de Jong, P G Postema, P H L T Bisschop, M J M Serlie, P Lips, E Dekker, N van der Velde, J M R Willemsen, L Vogt, J Schouten, P Portegies, B A Schmand, G J Geurtsen, F D Verbraak, N Demirkaya, I Visser, A Schadé, P T Nieuwkerk, N Langebeek, R P van Steenwijk, E Dijkers, C B L M Majoie, M W A Caan, T Su, H W van Lunsen, M A F Nievaard, B J H van den Born, E S G Stroes, W M C Mulder

Affiliations

¹ Department of Global Health.
² Amsterdam Institute for Global Health and Development.
³ Division of Infectious Diseases.
⁴ Center for Infection and Immunity Amsterdam.
⁵ HIV Monitoring Foundation.
⁶ Department of Experimental Immunology, Academic Medical Center.
⁷ Infectious Diseases Research, Public Health Service Amsterdam, The Netherlands.

PMID: 27683822
DOI: 10.1093/infdis/jiw459

Abstract

Smoking may affect cardiovascular disease risk more strongly in human immunodeficiency virus (HIV)-infected individuals than HIV-uninfected individuals. We hypothesized that an interaction at the level of the immune system may contribute to this increased risk. We assessed soluble markers of inflammation (high-sensitivity C-reactive protein [hsCRP]), immune activation (soluble [s]CD14 and sCD163), and coagulation (D-dimer) in HIV-infected and uninfected never, former, and current smokers. Smoking was independently associated with higher hsCRP levels and lower sCD163 levels and was borderline significantly associated with higher sCD14 and D-dimer levels. We found no evidence of a differential effect of smoking in HIV-infected individuals as compared to uninfected individuals.

Keywords: HIV infection; coagulation; inflammation; monocyte activation; smoking.

MeSH terms

Aged
Aged, 80 and over
Anti-Retroviral Agents / therapeutic use*
Antigens, CD / blood
Antigens, Differentiation, Myelomonocytic / blood
Blood Coagulation*
C-Reactive Protein / analysis
Cohort Studies
Female
Fibrin Fibrinogen Degradation Products / analysis
HIV Infections / drug therapy
HIV Infections / pathology*
Humans
Inflammation / pathology*
Lipopolysaccharide Receptors / blood
Male
Middle Aged
Monocytes / immunology*
Receptors, Cell Surface / blood
Smoking / adverse effects*

Substances

Anti-Retroviral Agents
Antigens, CD
Antigens, Differentiation, Myelomonocytic
CD163 antigen
Fibrin Fibrinogen Degradation Products
Lipopolysaccharide Receptors
Receptors, Cell Surface
fibrin fragment D
C-Reactive Protein