Abstract
Roots of Nepenthes thorelii yielded plumbagin, 2-methylnaphthazarin, octadecyl caffeate, isoshinanolone, and droserone. In addition, seven derivatives were prepared from plumbagin. Each of these natural and semisynthetic compounds was evaluated for in vitro antimalarial potential.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimalarials / chemistry*
-
Antimalarials / pharmacology
-
Drug Evaluation, Preclinical
-
Naphthoquinones / chemistry*
-
Naphthoquinones / pharmacology
-
Plant Extracts / chemistry*
-
Plant Extracts / pharmacology
-
Plant Roots
-
Plasmodium falciparum / drug effects
Substances
-
Antimalarials
-
Naphthoquinones
-
Plant Extracts