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Dabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority …

…, A Galustyan, J Hak, M Hoffmann, A Kupesiz… - The Lancet …, 2021 - thelancet.com
Background Dabigatran etexilate is a direct oral anticoagulant with potential to overcome
the limitations of standard of care in children with venous thromboembolism. The aims of this …

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

…, Ş Haskoloğlu, M Gökalp Bolkent, A Küpesiz… - Nature …, 2014 - nature.com
Primary immunodeficiency disorders enable identification of genes with crucial roles in the
human immune system. Here we study patients suffering from recurrent bacterial, viral and …

Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis

…, C Klein, A Kulagin, A Kupesiz… - Blood, The Journal …, 2022 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment
for patients affected by Wiskott-Aldrich syndrome (WAS). Reported HSCT outcomes have …

[HTML][HTML] Hematopoietic cell transplantation in severe combined immunodeficiency: the SCETIDE 2006-2014 European cohort

…, A Ikinciogullari, K Kalwak, S Kansoy, A Kupesiz… - Journal of Allergy and …, 2022 - Elsevier
Background Hematopoietic stem cell transplantation (HSCT) represents a curative treatment
for patients with severe combined immunodeficiency (SCID), a group of monogenic immune …

[HTML][HTML] Prophylaxis vs. on‐demand treatment with BAY 81‐8973, a full‐length plasma protein‐free recombinant factor VIII product: results from a randomized trial …

…, K Kavakli, B Antmen, I Sasmaz, A Kupesiz… - Journal of Thrombosis …, 2015 - Elsevier
Background BAY 81‐8973 is a new full‐length human recombinant factor VIII product
manufactured with technologies to improve consistency in glycosylation and expression to …

Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

…, S Robinson, Y Bertrand, A Kupesiz… - Bone marrow …, 2020 - nature.com
Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total
body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem …

Childhood acute lymphoblastic leukemia in Turkey: factors influencing treatment and outcome: a single center experience

…, GT Karasu, V Uygun, M Akcan, A Küpesiz… - Journal of pediatric …, 2010 - journals.lww.com
There is limited data about the long-term treatment outcome and prognosis of childhood acute
lymphoblastic leukemia (ALL) in developing countries. Our study was designed to assess …

Gene therapy in haemophilia: literature review and regional perspectives for Turkey

…, E Berber, Z Kaya, A Küpesiz… - Therapeutic …, 2022 - journals.sagepub.com
Haemophilia is an X-linked lifelong congenital bleeding disorder that is caused by
insufficient levels of factor VIII (FVIII; haemophilia A) or factor IX (FIX; haemophilia B) and …

Tissue plasminogen activator induced fibrinolysis: standardization of method using thromboelastography

A Kupesiz, M Rajpurkar, I Warrier… - Blood Coagulation & …, 2010 - journals.lww.com
Fibrinolysis is a complex physiological process that involves the interaction of several
anticoagulant proteins. Defects of the fibrinolytic system are extremely difficult to diagnose and …

Thalassemia-free and graft-versus-host-free survival: outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience

MA Yesilipek, V Uygun, A Kupesiz, G Karasu… - Bone Marrow …, 2022 - nature.com
We report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT)
for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell …
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