Mammalian cells have three ATP-dependent DNA ligases, which are required for DNA
replication and repair 1 . Homologues of ligase I (Lig1) and ligase IV (Lig4) are ubiquitous in …

Chromosomal translocations in hematologic and mesenchymal tumors form overwhelmingly
by nonhomologous end-joining (NHEJ). Canonical NHEJ, essential for the repair of …

During eukaryotic evolution, ribosomes have considerably increased in size, forming a
surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an interface …

Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie
chromosomal translocations and other genomic rearrangements in somatic cells. The …

Günlük hayatta, herhangi biri ile konuşurken, sırada beklerken ya da iş yaşamımızda genellikle
birkaç dakikadan daha uzun süre ayakta durmak zorunda kalırız. Bu gibi doğal duruşlar …

The precise genetic manipulation of stem and precursor cells offers extraordinary potential
for the analysis, prevention, and treatment of human malignancies. Chromosomal …

Airlines tend to design their flights schedules with the primary concern of the minimization of
operational costs. However, the recently emerging idea of resilient scheduling defined as …

The ribosome is one of life’s most ancient molecular machines that has historically been
viewed as a backstage participant in gene regulation, translating the genetic code across all …

Available data and models for the health-economic evaluation of treatment in Alzheimer's
disease (AD) have limitations causing uncertainty to decision makers. Forthcoming treatment …

DNA ligases are crucial for most DNA transactions, including DNA replication, repair, and
recombination. Recently, DNA ligase III (Lig3) has been demonstrated to be crucial for cell …