User profiles for Jawaher Alsughayyir

Jawaher Alsughayyir

Transplantation and autoimmunity
Verified email at ksu.edu.sa
Cited by 447

[HTML][HTML] Spoiling for a fight: B lymphocytes as initiator and effector populations within tertiary lymphoid organs in autoimmunity and transplantation

J Alsughayyir, GJ Pettigrew… - Frontiers in …, 2017 - frontiersin.org
Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues,
such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from …

[HTML][HTML] T-Cell subsets and interleukin-10 levels are predictors of severity and mortality in COVID-19: A systematic review and meta-analysis

AF Alshammary, JM Alsughayyir, KK Alharbi… - Frontiers in …, 2022 - frontiersin.org
Background: A large number of COVID-19 patients reveal a marked decrease in their lymphocyte
counts—a condition that translates clinically into the state of immunodepression, which …

Relative frequencies of alloantigen-specific helper CD4 T cells and B cells determine mode of antibody-mediated allograft rejection

J Alsughayyir, M Chhabra, MS Qureshi… - Frontiers in …, 2019 - frontiersin.org
Humoral alloimmunity is now recognized as a major determinant of transplant outcome.
MHC glycoprotein is considered a typical T-dependent antigen, but the nature of the T cell …

Monocyte–Lymphocyte Ratio and Dysglycemia: A Retrospective, Cross-Sectional Study of the Saudi Population

MA Alfhili, J Alsughayyir, AM Basudan, R Alsubki… - Healthcare, 2022 - mdpi.com
Background: Abnormalities in fasting blood glucose (FBG) resulting in hypoglycemia (OG),
impaired fasting glycemia (IFG), or hyperglycemia (HG) arise from disordered metabolic …

Isolated and Combined Effect of Age and Gender on Neutrophil–Lymphocyte Ratio in the Hyperglycemic Saudi Population

MA Alfhili, J Alsughayyir, A Basudan, HK Ghneim… - Medicina, 2022 - mdpi.com
Inflammation is pivotal to the pathogenesis of diabetes mellitus (DM), but pathological
alterations of the neutrophil–lymphocyte ratio (NLR), an emerging inflammatory index in DM …

[HTML][HTML] Demography and blood donation trends in Saudi Arabia: A nationwide retrospective, cross-sectional study

J Alsughayyir, Y Almalki, M Alalshaik, I Aljoni… - Saudi Journal of …, 2022 - Elsevier
Background Blood product supply and utilization are understudied in Saudi Arabia. This
study evaluates the trends in Saudi blood banks readiness, donors’ demography, and blood …

[HTML][HTML] GSK-3-associated signaling is crucial to virus infection of cells

MA Alfhili, J Alsughayyir, JA McCubrey… - Biochimica et Biophysica …, 2020 - Elsevier
Signal transduction pathways play important roles in virus infection, replication, and associated
pathogenesis. Some of the best understood cell signaling networks are crucial to virus …

Stimulation of hemolysis and eryptosis by α-Mangostin through Rac1 GTPase and oxidative injury in human red blood cells

SA Alghareeb, J Alsughayyir, MA Alfhili - Molecules, 2023 - mdpi.com
Background: Chemotherapy-related anemia is prevalent in up to 75% of patients, which
may arise due to hemolysis and eryptosis. Alpha-mangostin (α-MG) is a polyphenolic …

[HTML][HTML] Blood indices of omega-3 and omega-6 polyunsaturated fatty acids are altered in hyperglycemia

MA Alfhili, J Alsughayyir, A Basudan, M Alfaifi… - Saudi Journal of …, 2023 - Elsevier
Polyunsaturated fatty acids (PUFAs) may favorably influence the risk and clinical course of
diabetes mellitus (DM). In particular, eicosapentaenoic acid (EPA), docosahexaenoic acid (…

Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death

MA Alfhili, J Alsughayyir - Xenobiotica, 2023 - Taylor & Francis
Deguelin (DGN), a retinoid isolated from many plants, exhibits a potent anticancer activity
against a wide spectrum of tumour cells. There is a dearth of evidence, however, regarding the …