Novel carbazole-oxadiazoles were developed as new potential antibacterial agents to combat
dreadful resistance. Some target compounds displayed predominant inhibitory effects on …

Isocyanide-based multicomponent reactions are among the most powerful synthetic tools
available. Particularly, the isocyanide-based Ugi reaction can allow rapid preparation of $$\…

With the soaring of bacterial infection and drug resistance, it is imperative to exploit new
efficient antibacterial agents. This work constructed a series of unique phenylhydrazone-based …

The efficacy and resistance of cisplatin-based compounds are very intractable problems at
present. This study reports a series of platinum(IV) compounds containing multiple-bond …

Structurally unique 2,2-disubstituted indolin-3-ones with a quaternary carbon center have
been constructed through a novel C–C bond formation at the C3 position of Ugi N-acylamino …

A novel type of sulfonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial
agents was constructed via the unique ring-opened reaction of oxiranes by imidazoles for …

Insulin resistance is a fundamental pathogenic factor present in various metabolic disorders
including obesity and type 2 diabetes 1 . Although skeletal muscle accounts for 70–90% of …

A novel three-component cascade reaction was discovered and developed to synthesize
pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles …

Two thermally stable MOFs formulated as CoL(1,4-bdc)·2DMF (L = 3,5-bis(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)pyridine),
1,4-H2bdc = 1,4-benzenedicarboxylic acid) (1) and CdL(4,4′-…

To identify Streptococcus pneumoniae genes expressed specifically during infections, a
selection system based on the in vivo expression technology (IVET) was established. galU, …