Malignant lymphocyte migration into lymph nodes is an important aspect of chronic lymphocytic
leukemia (CLL), yet little is known about the processes involved. Here we demonstrate …

Local and systemic haemorrhage are common consequences of crotaline and viperine
envenoming. Several studies carried out using purified toxins have indicated that local …

Expansion of primary solid tumors and their malignant dissemination are angiogenesis-dependent.
Vascular endothelial growth factor (VEGF) is the key factor playing a pivotal role in …

Hairy cells (HCs) are mature malignant B cells that contain a number of constitutively active
signaling molecules including GTP-bound Rac1, protein kinase C, and Src family kinases. …

Background The endothelial protein C receptor plays an important role within the protein C
pathway in regulating coagulation and inflammation. Recently, we described that endothelial …

Jararhagin is a high-molecular-mass (52 kDa) haemorrhagic metalloproteinase from Bothrops
jararacavenom and a member of the metalloproteinase/disintegrin/cysteine-rich protein …

Matrix metalloproteinases (MMPs) are important for the pathogenesis and progression of
different tumours. MMPs‐2 and ‐9 are the principal MMPs produced by lymphocytes; these …

Signals through the B-cell antigen receptor (BCR) are important for the survival of chronic
lymphocytic leukemia (CLL) cells. Therefore, factors that influence these signals have …

Vascular endothelial cell growth factor (VEGF) is a multifunctional cytokine involved in
tumor formation. In chronic lymphocytic leukemia (CLL), it is known that the malignant cells …

… Mirko Zuzel, Mirko Zuzel … Zoltan Matrai, Ke Lin, Michael Dennis, Paul Sherrington, Mirko
Zuzel, Andrew R Pettitt, John C. Cawley; CD38 expression and Ig V H gene mutation in B-cell …