Sitagliptin is selective dipeptidyl peptidase-4 inhibitor (DPP4-I), used clinically as a new oral
anti-diabetic agent. This study explored the underlying mechanisms of the hepatoprotective …

Background/purpose Pristimerin (Pris) is triterpenoid compound with many biological effects.
Until now, nothing is known about its effect on doxorubicin (DOX)-induced cardiotoxicity. …

The objective was to study the in-vivo protective effect of Al-Madinah Ajwa dates extract
against lead acetate toxicity on the tissues of vital organs. Four rabbit groups were used as an …

There is a large body of evidence suggesting that inhibitors of dipeptidyl peptidase-4, such
as sitagliptin, may exhibit beneficial effects against different inflammatory disorders. This …

Endotoxemia-induced hepatotoxicity is characterized by disturbed intracellular redox
balance, excessive reactive oxygen species (ROS) generation inducing DNA, proteins and …

Purpose Cyclophosphamide (CP) is a frequently used anticancer and immunosuppressant
although its use has been associated with severe cardiotoxicity. The present study examined …

This study targeted to test the potential protective role of lutein against lung and liver damage
associated with cyclophosphamide (CP) administration. Lutein was given orally for 5 days …

Garcinia mangostana L. (GM, family Guttiferae) is one of the most widely recognized tropical
fruits. GM is a wealthy pool of xanthones that exhibit a wide range of bioactivities. …

Pristimerin (Pris) is bioactive natural quinonoid triterpene that has anti-inflammatory and anti-cancer
activities. Meanwhile, its effect against hepatitis needs to be elucidated. This …

Objectives: To evaluate Ki67 immunoexpression pattern in Saudi breast cancer (BC) patients
and investigate any possible predictive or prognostic value for Ki67. Methods: This is a …