Cancer stem cells (CSCs) or tumor‐initiating cells (TICs) as a small subset of neoplastic cells
are able to produce a tumor (tumorigenesis), maintain the population of tumorigenic cells (…

AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum
samples, its impact on p16-protein expression, and correlation with clinical and histological …

The city of Mashhad is the capital of Khorasan, the northeastern province of Iran, which has
been recognized as an area where human T-lymphotropic virus type 1 (HTLV-1) infection is …

Background Human cancer cells resemble stem cells in expression signatures leading
them to share some features, most notably, self-renewal. A complex network of transcription …

Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic
stem cells (ESCs) such as self-renewal and maintenance of stemness state. SALL4 and SOX2 …

Background Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2
are considered to be essential G1 cell cycle regulatory genes whose loss of function is …

ContextGenetic testing for hereditary nonpolyposis colon cancer (HNPCC) is available, but
the rates of acceptance of testing or barriers to participation are not known.ObjectiveTo …

Background Ovarian cancer has the highest ratio of mortality among gynecologic
malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer. …

Background Sharing the role of immune suppression, interleukin-10 (IL-10), transforming
growth factor β (TGF-β), and vascular endothelial growth factor (VEGF) are critical genes in …

Purpose Colorectal cancer (CRC) is one of the most common causes of cancer-related death
worldwide, and there is an urgent need to identify critical diagnostic and prognostic factors …