Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease

…, H Javed, A Ahmad, A Khan, F Islam, MM Safhi… - Neurotoxicity …, 2012 - Springer
This study was undertaken to investigate the neuroprotective effects of rutin (vitamin P) on 6-hydroxydopamine
(6-OHDA)-induced Parkinson’s disease (PD) in rats. Oxidative stress and …

Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat …

…, F Islam, M Saeed Siddiqui, MM Safhi… - Molecular and cellular …, 2012 - Springer
The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery
occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of …

[HTML][HTML] Vaccine adjuvants–current status and prospects on controlled release adjuvancity

SM Sivakumar, MM Safhi, M Kannadasan… - Saudi Pharmaceutical …, 2011 - Elsevier
The strategy of World Health Organization is to develop efficient and inexpensive vaccine
against various infectious diseases amongst children’s population. Vaccination is considered …

Anti-apoptotic and anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's rat model

…, T Ishrat, MM Khan, A Ahmad, F Islam, MM Safhi… - The Journal of …, 2013 - Elsevier
In the present study, we examined the molecular mechanism by which Piperine (bioactive
compound of Piper nigrum) inhibits neuronal cell apoptosis. We further investigated the anti-…

S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia …

…, R Tabassum, MS Siddiqui, OM El-Agnaf, MM Safhi… - Brain research, 2011 - Elsevier
S-allyl cysteine (SAC), a sulfur containing amino acid derived from garlic, has been reported
to have antioxidant, anti-cancer, antihepatotoxic and neurotrophic activity. This study was …

Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke

…, R Tabassum, H Javed, MS Siddiqui, MM Safhi… - Brain Research, 2011 - Elsevier
Incidence of stroke is considered to be a major cause of death throughout the world. The
middle cerebral artery occlusion (MCAO) for 2h followed by 22h of reperfusion model was used …

Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion

…, T Ishrat, M Ashafaq, ME Ahmad, MM Safhi… - Neurochemical …, 2011 - Springer
Experimental studies have demonstrated that oxidative stress and apoptosis play an important
role in cerebral ischemic pathogenesis and may represent a target for treatment. The …

Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

…, R Tabassum, M Ashafaq, F Islam, MM Safhi… - Neurochemistry …, 2013 - Elsevier
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder resulting in cognitive
decline and enhancement of oxidative loads in the brain. Flavonoids have been considered …

Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment …

…, A Khan, R Tabassum, F Islam, MM Safhi… - Journal of the …, 2015 - Elsevier
Recent attention is given to the influence of dietary supplementation on health and mental
well-being. Oxidative stress is associated with many diseases including neurodegenerative …

Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar …

…, G Khuwaja, A Khan, MS Siddiqui, MM Safhi… - Journal of the …, 2011 - Elsevier
Cerebral stroke is the third largest cause of death and the severe leading cause of disability,
thus have astronomical financial and social burden worldwide. Accumulated evidence …