Global gene expression analysis has been a major tool for urothelial carcinoma subtype
discovery. This approach has revealed extensive complexity both in intrinsic features of the …

Purpose Autosomal recessive retinitis pigmentosa (arRP) is a genetically heterogeneous
disease resulting in progressive loss of photoreceptors that leads to blindness. To date, 36 …

Molecular changes occurring during invasion and clinical progression of cancer are difficult
to study longitudinally in patient‐derived material. A unique feature of urothelial bladder …

Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the
bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the …

Molecular subtypes of urothelial carcinoma may be divided into luminal and nonluminal
tumors. Nonluminal tumors are composed of cases with basal/squamous‐like or small cell/…

The Human leukocyte antigen (HLA) molecules are central to immune response and have
associations with the phenotypes of various diseases and induced drug toxicity. Further, the …

Motivation Gene expression-based multiclass prediction, such as tumor subtyping, is a non-trivial
bioinformatic problem. Most classifier methods operate by comparing expression …

Generalized vitiligo is a common autoimmune disorder, characterized by patchy loss of
pigmentation due to melanocyte death. It is a multifactorial disorder in which multiple genes and …

The Illumina Infinium HumanMethylation450 BeadChip (450k) is widely used for the
evaluation of DNA methylation levels in large-scale datasets, particularly in cancer. The 450k …

EMAP (Extensive Macular Atrophy with Pseudodrusen) is a maculopathy we recently described
that shares pseudodrusen and geographic atrophy with Age-related Macular Disease (…