Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

Alternative splicing of human cystic fibrosis transmembrane conductance regulator (CFTR)
exon 9 is regulated by a combination of cis‐acting elements distributed through the exon and …

Several susceptibility genes differentially impact on the lifetime risk for breast cancer.
Technological advances over the past years have enabled the detection of genetic risk factors …

The Breast Cancer Association Consortium (BCAC) has been established to conduct combined
case-control analyses with augmented statistical power to try to confirm putative genetic …

Background: Data for multiple common susceptibility alleles for breast cancer may be combined
to identify women at different levels of breast cancer risk. Such stratification could guide …

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 …

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility
loci, but these explain only a small fraction of the familial risk of the disease. Five of these …

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy,
responsible for 13 000 deaths per year in the United States. Risk prediction based on …

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed
countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-…