Ferroptosis is a form of iron-dependent regulated cell death. Evidence of its existence and
the effects of its inhibitors on subarachnoid hemorrhage (SAH) is still lacking. In the present …

The transdermal administration of chemotherapeutic agents is a persistent challenge for
tumor treatments. A model anticancer agent, epirubicin (EPI), is attached to functionalized …

Purpose Safe and effective lipid nanoemulsion (LNE) formulations for the antitumor delivery
of doxorubicin is designed. Methods LNEs composed of medium-chain triglyceride, soybean …

Autophagy is an evolutionarily conserved cellular process that primarily participates in
lysosome-mediated protein degradation. Although autophagy is a cytoplasmic event, how …

Cancer cells reprogram their energy metabolic system from the mitochondrial oxidative
phosphorylation (OXPHOS) pathway to a glucose-dependent aerobic glycolysis pathway. This …

Objective. The Chronic Care Model, based on core elements of team-centered care in chronic
diseases, has widely been accepted. This study was aimed at evaluating the effectiveness …

Context Cancer treatment capacity in China is severely limited relative to the enormous size
of the population; and many aspects of treatment, such as opioid protocols for pain control, …

Background: Correct dosing of antimicrobial drugs in septic patients receiving continuous
renal replacement therapy (CRRT) is complex. This study aimed to evaluate the effects of …

Because numerous challenges limit the effective oral delivery of protein and peptide drugs,
we developed promising chitosan (CS)-modified, dual drug-loaded nanoparticles (NPs) …

Parasitic infection improves metabolic homeostasis in “western diet”-induced obesity
through the regulation of adipogenesis. However, the underlying mechanism is not yet fully …