[HTML][HTML] Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter
Á Telbisz, M Müller, C Özvegy-Laczka… - … et Biophysica Acta (BBA …, 2007 - Elsevier
The human ABCG2 multidrug transporter provides protection against numerous toxic compounds
and causes multidrug resistance in cancer. Here we examined the effects of changes …
and causes multidrug resistance in cancer. Here we examined the effects of changes …
[HTML][HTML] Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics
…, É Bakos, B Sarkadi, C Özvegy-Laczka, Á Telbisz - Scientific Reports, 2021 - nature.com
Transporters in the human liver play a major role in the clearance of endo- and xenobiotics.
Apical (canalicular) transporters extrude compounds to the bile, while basolateral …
Apical (canalicular) transporters extrude compounds to the bile, while basolateral …
[HTML][HTML] Inhibitory effects of quercetin and its main methyl, sulfate, and glucuronic acid conjugates on cytochrome P450 enzymes, and on OATP, BCRP and MRP2 …
…, O Ungvári, K Kuffa, PW Needs, PA Kroon, Á Telbisz… - Nutrients, 2020 - mdpi.com
Quercetin is a flavonoid, its glycosides and aglycone are found in significant amounts in
several plants and dietary supplements. Because of the high presystemic biotransformation of …
several plants and dietary supplements. Because of the high presystemic biotransformation of …
[HTML][HTML] Interactions of potential anti-COVID-19 compounds with multispecific ABC and OATP drug transporters
During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate
the major health effects of the disease. These drugs are often applied with analgesics or non…
the major health effects of the disease. These drugs are often applied with analgesics or non…
Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes and on OATP, P-gp, BCRP, and …
Chrysin is an abundant flavonoid in nature, and it is also contained by several dietary
supplements. Chrysin is highly biotransformed in the body, during which conjugated metabolites …
supplements. Chrysin is highly biotransformed in the body, during which conjugated metabolites …
Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function
Á Telbisz, L Homolya - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of
hepatocyte, mediates the secretion of bile salts into the bile. A range of human diseases is …
hepatocyte, mediates the secretion of bile salts into the bile. A range of human diseases is …
Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein
Á Telbisz, C Özvegy-Laczka, T Hegedűs… - Biochemical …, 2013 - portlandpress.com
The human ABCG2 multidrug transporter actively extrudes a wide range of hydrophobic
drugs and xenobiotics recognized by the transporter in the membrane phase. In order to …
drugs and xenobiotics recognized by the transporter in the membrane phase. In order to …
Ins and outs of the ABCG2 multidrug transporter: an update on in vitro functional assays
The major aim of this chapter is to provide a critical overview of the in vitro methods available
for studying the function of the ABCG2 multidrug transporter protein. When describing the …
for studying the function of the ABCG2 multidrug transporter protein. When describing the …
Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites
ABCG2 (ATP-binding cassette, subfamily G, member 2) is a plasma membrane glycoprotein
that actively extrudes xenobiotics and endobiotics from the cells and causes multidrug …
that actively extrudes xenobiotics and endobiotics from the cells and causes multidrug …
Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter
Á Telbisz, C Hegedüs, C Özvegy-Laczka… - European journal of …, 2012 - Elsevier
The ABCG2 multidrug transporter protein has been identified as a key player in cancer drug
resistance and xenobiotic elimination, as its actively transported substrates include …
resistance and xenobiotic elimination, as its actively transported substrates include …