Cten promotes Epithelial–Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src

…, M Akhlaq, H Thorpe, A Alfahed… - Pathology …, 2019 - Wiley Online Library
Cten is an oncogene promoting EMT in many signaling pathways, namely through Snail.
We investigated whether Cten function could be mediated through Src. Cten levels were …

[HTML][HTML] Integrated exon level expression analysis of driver genes explain their role in colorectal cancer

…, Z Al Yousef, I AlAbdulkarim, M Al Otaibi, A Alfahed… - PLoS …, 2014 - journals.plos.org
Integrated analysis of genomic and transcriptomic level changes holds promise for a better
understanding of colorectal cancer (CRC) biology. There is a pertinent need to explain the …

TGF β1‐induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer

A Asiri, TP Raposo, A Alfahed… - International Journal of …, 2018 - Wiley Online Library
Cten (C‐terminal tensin‐like) is a member of the tensin protein family found in complex with
integrins at focal adhesions. It promotes epithelial‐mesenchymal transition ( EMT ) and cell …

[HTML][HTML] Immunohistochemical expression of survivin and KI-67 as tumor markers in breast cancer infected females: A cross-sectional study

…, NE Obaid, S Abdelghani, A Alfahed… - …, 2020 - pharmacophorejournal.com
Survivin is a part of the apoptosis inhibitor group. It is implicated in the control of the cell
division and is commonly distributed in fetal tissues and human tumors, and is never expressed …

A molecular informatics and in-vitro approach to evaluate the HMG-CoA reductase inhibitory efficacy of monoterpenes, carvacrol and geraniol

…, HH Ahmed, P Ahmad, A Alfahed… - Journal of Taibah …, 2024 - Taylor & Francis
Currently, statins, the β-hydroxy-β-methyl-glutaryl-CoA reductase (HMG-R) inhibitors, are
widely used to lower cholesterol, nevertheless, they have several side effects. Consequently, …

[HTML][HTML] Prognostic Values of Gene Copy Number Alterations in Prostate Cancer

A Alfahed, HO Ebili, NE Almoammar, G Alasiri… - Genes, 2023 - mdpi.com
Whilst risk prediction for individual prostate cancer (PCa) cases is of a high priority, the current
risk stratification indices for PCa management have severe limitations. This study aimed …

[HTML][HTML] Alternatively Spliced Isoforms of MUC4 and ADAM12 as Biomarkers for Colorectal Cancer Metastasis

…, B Alghanem, SA Alsagaby, A Alfahed… - Journal of Personalized …, 2023 - mdpi.com
There is a pertinent need to develop prognostic biomarkers for practicing predictive,
preventive and personalized medicine (PPPM) in colorectal cancer metastasis. The analysis of …

[HTML][HTML] The role of TAOK3 in cancer progression and development as a prognostic marker: A pan-cancer analysis study

…, JA Aldali, AM Aljehani, A Alfahed… - Saudi Pharmaceutical …, 2024 - Elsevier
The protein kinase TAOK3, belongs to the MAP kinase family, is one of three closely related
members, namely TAOK1, TAOK2, and TAOK3. We performed a pan-cancer investigation of …

[HTML][HTML] Deregulation of TWIST1 expression by promoter methylation in Gastrointestinal Cancers

A Alfahed - Saudi Journal of Biological Sciences, 2023 - Elsevier
TWIST1, a basic helix-loop-helix transcription factor with versatile roles in cancer, is
frequently deregulated in cancers, through established pathway perturbations. However. the …

[HTML][HTML] Molecular pathology of colorectal cancer: The Saudi situation in perspective

A Alfahed - Saudi Medical Journal, 2023 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common cancers worldwide, and one of the most
common causes of cancer deaths. In recent times, significant advancements have been …