We have found that an important Th2 cytokine, IL-10, is produced by tissues from patients
acutely infected with Leishmania donovani. In all individuals tested, IL-10 mRNA production …

Madurella mycetomatis is the commonest cause of eumycetoma in Sudan and other countries
in tropical Africa. Currently, the early diagnosis of mycetoma is difficult. In attempting to …

Breast cancer is the commonest cancer in Sudanese women. Reported genetic alterations in
the form of mutations in tumor suppressors are low in frequencies and could not explain the …

IL-12 is a pluripotent cytokine that interacts with NK and T cells to play a central role in the
initiation and maintenance of Th1 responses and IFN-gamma production. Because of the …

An evaluation of Leishmania PCR was performed with bone marrow, lymph node, and blood
samples from 492 patients, 60 positive controls, and 90 negative controls. Results were …

PKDL develops in about 50% of Sudanese patients treated for visceral leishmaniasis (kala-azar).
Patients with kala-azar were entered into this study and followed for a period of up to 2 …

Background Anti-leishmanial drug regimens that include a single dose AmBisome® could
be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the …

The authors describe the clinical and laboratory findings in 25 male and 21 female Sudanese
patients suffering from primary paranasal Aspergillus granuloma (PAG). The patients …

Post-kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-γ
(IFN-γ). To study interferon-γ pathways in PKDL, we genotyped 80 trios from the Masalit …

The presence of a geographical pattern in the distribution of the sickle cell gene (S gene)
and its association with malaria is well documented. To study the distribution of the S gene …