To identify genes potentially playing an important role in the progression of colorectal carcinoma
(CRC), we screened global gene expression using cDNA expression array on 41 CRC …

BACKGROUND AND OBJECTIVES : The national data on colorectal cancer in Saudi Arabia
has not been analyzed. The objective of this study is to describe the demographics, …

BACKGROUND : Colorectal cancer is the most common cancer among Saudi men and the
third commonest among Saudi women. Given the predominance of colorectal cancer …

This study examined the chemopreventive effect of Nigella sativa and some of its antioxidant
constituents on a number of colon cancer biomarkers in rats induced with azoxymethane (…

Somatic KRAS mutation is an early well‐known event in colorectal carcinogenesis but a
complete understanding of RAS function and dysfunction in colorectal cancer is still to come. …

Substantial evidence implicates the ubiquitin-conjugating enzyme E2C (UBE2C) gene, in
several human cancers, including colorectal carcinoma (CRC). We therefore investigated the …

S-phase kinase protein 2 (SKP2), an F-box protein, targets cell cycle regulators including
cycle-dependent kinase inhibitor p27Kip1 via ubiquitin-mediated degradation. SKP2 is …

… Alaa Abdul Jabbar, MD: contributed substantially to the acquisition and interpretation of
clinical data, participated in revising the content of the manuscript, and gave final approval for …

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. In Saudi
Arabia, colorectal cancer is more aggressive and presents at younger age, warranting new …

We investigated the role of leptin receptor (Ob-R) and its relationship with phosphatidylinositol
3-kinase (PI3K)/AKT activation in colorectal carcinomas (CRCs) tissues followed by in …