Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila

…, JC Sierra, J Sha, S Wang, TE Erova, AA Fadl… - Microbial …, 2008 - Elsevier
Our laboratory recently molecularly characterized the type II secretion system (T2SS)-associated
cytotoxic enterotoxin (Act) and the T3SS-secreted AexU effector from a diarrheal isolate …

Early Bacillus anthracis–macrophage interactions: intracellular survival and escape

TC Dixon, AA Fadl, TM Koehler… - Cellular …, 2000 - Wiley Online Library
This study describes early intracellular events occurring during the establishment phase of
Bacillus anthracis infections. Anthrax infections are initiated by dormant endospores gaining …

[HTML][HTML] tRNA modification enzymes GidA and MnmE: potential role in virulence of bacterial pathogens

DC Shippy, AA Fadl - International journal of molecular sciences, 2014 - mdpi.com
Transfer RNA (tRNA) is an RNA molecule that carries amino acids to the ribosomes for protein
synthesis. These tRNAs function at the peptidyl (P) and aminoacyl (A) binding sites of the …

Distribution of Virulence Factors and Molecular Fingerprinting of Aeromonas Species Isolates from Water and Clinical Samples: Suggestive Evidence of Water-to …

BK Khajanchi, AA Fadl, MA Borchardt… - Applied and …, 2010 - Am Soc Microbiol
A total of 227 isolates of Aeromonas obtained from different geographical locations in the
United States and different parts of the world, including 28 reference strains, were analyzed to …

[HTML][HTML] Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264. 7 murine macrophages

KV Ramana, AA Fadl, R Tammali, ABM Reddy… - Journal of Biological …, 2006 - ASBMB
Abnormal production of inflammatory cytokines and chemokines is a key feature of bacterial
endotoxin, lipopolysaccharide (LPS)-induced inflammation, and cytotoxicity; however, the …

[HTML][HTML] Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal …

CL Galindo, AA Fadl, J Sha, C Gutierrez… - Journal of Biological …, 2004 - ASBMB
A cytotoxic enterotoxin (Act) of Aeromonas hydrophila possesses several biological activities,
induces an inflammatory response in the host, and causes apoptosis of murine …

The Type III Secretion System and Cytotoxic Enterotoxin Alter the Virulence of Aeromonas hydrophila

J Sha, L Pillai, AA Fadl, CL Galindo… - Infection and …, 2005 - Am Soc Microbiol
Many gram-negative bacteria use a type III secretion system (TTSS) to deliver effector proteins
into host cells. Here we report the characterization of a TTSS chromosomal operon from …

Braun lipoprotein (Lpp) contributes to virulence of yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague

J Sha, SL Agar, WB Baze, JP Olano, AA Fadl… - Infection and …, 2008 - Am Soc Microbiol
Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of
bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar …

Interaction between innate immune cells and a bacterial type III secretion system in mutualistic and pathogenic associations

AC Silver, Y Kikuchi, AA Fadl, J Sha… - Proceedings of the …, 2007 - National Acad Sciences
Animals house a community of bacterial symbionts in their digestive tracts that contribute to
their well being. The medicinal leech, Hirudo verbana, has a remarkably simple gut …

Host immune responses to Aeromonas virulence factors

CL Galindo, J Sha, AA Fadl, LL Pillai… - Current Immunology …, 2006 - ingentaconnect.com
Aeromonas species are emerging human pathogens, which produce an array of virulence
factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria …