Despite limited data, polymyxin B (PB) is increasingly used clinically as the last therapeutic
option for multidrug-resistant (MDR) gram-negative bacterial infections. We examined the in …

Suppression of resistance in a dense Pseudomonas aeruginosa population has previously
been shown with optimized quinolone exposures. However, the relevance to β-lactams is …

Good parent and differential allocation models predict relationships between degree of sexual
ornamentation and parental care, but relatively few studies have tested these models. The …

Objectives: Time–kill studies are commonly used in investigations of new antimicrobial
agents. However, they typically provide descriptive information on pharmacodynamics. We …

Aminoglycosides are often used to treat severe infections with gram-positive organisms.
Previous studies have shown concentration-dependent killing by aminoglycosides of gram-…

The US Food and Drug Administration (FDA), concerned about the incidence of acute liver
failure due to acetaminophen (Tylenol) overdose, has mandated new labeling on …

Primary neuroendocrine carcinoma of the breast is a rare variant, accounting for only 2% to
5% of diagnosed breast cancers, and may have relatively aggressive behavior. Mutational …

Because a significant proportion of Staphylococcus aureus strains as well as most
coagulase-negative staphylococci are resistant to penicillin and semisynthetic beta-lactam drugs, the …

We examined the prevalence of various carbapenem resistance mechanisms in Pseudomonas
aeruginosa bloodstream isolates from a university-affiliated hospital. Isolates obtained in …

Somatic mutations in PIK3CA are commonly seen in invasive breast cancer and several other
carcinomas, occurring in three hotspots: codons 542 and 545 of exon 9 and in codon 1047 …