User profiles for Ashraf Ibrahim

Ashraf Ibrahim

David Geffen School of Medicine at UCLA; The Lundquist Institute at Harbor-UCLA Medical …
Verified email at lundquist.org
Cited by 22877

Novel perspectives on mucormycosis: pathophysiology, presentation, and management

…, J Edwards Jr, A Ibrahim - Clinical microbiology …, 2005 - Am Soc Microbiol
Mucormycosis is a life-threatening fungal infection that occurs in immunocompromised patients.
These infections are becoming increasingly common, yet survival remains very poor. A …

Pathogenesis of mucormycosis

AS Ibrahim, B Spellberg, TJ Walsh… - Clinical infectious …, 2012 - academic.oup.com
Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised
because of diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased …

[HTML][HTML] Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice

L Lin, AS Ibrahim, X Xu, JM Farber, V Avanesian… - PLoS …, 2009 - journals.plos.org
We sought to define protective mechanisms of immunity to Staphylococcus aureus and Candida
albicans bloodstream infections in mice immunized with the recombinant N-terminus of …

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the …

…, J Guinea, CP Heussel, AS Ibrahim… - The Lancet infectious …, 2019 - thelancet.com
Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality.
Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical …

Recent advances in the management of mucormycosis: from bench to bedside

…, J Edwards Jr, AS Ibrahim - Clinical Infectious …, 2009 - academic.oup.com
Recent therapeutic advances have the potential to improve outcomes of mucormycosis. Lipid
formulations of amphotericin B (LFAB) have evolved as the cornerstone of primary therapy …

[HTML][HTML] Genomic Analysis of the Basal Lineage Fungus Rhizopus oryzae Reveals a Whole-Genome Duplication

LJ Ma, AS Ibrahim, C Skory, MG Grabherr… - PLoS …, 2009 - journals.plos.org
Rhizopus oryzae is the primary cause of mucormycosis, an emerging, life-threatening infection
characterized by rapid angioinvasive growth with an overall mortality rate that exceeds 50…

[HTML][HTML] COVID-19-associated fungal infections

…, C Cunha, M Oliverio, GH Goldman, AS Ibrahim… - Nature …, 2022 - nature.com
Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an important
complication in a substantial number of critically ill, hospitalized patients with COVID-19. …

[HTML][HTML] Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells

…, MR Yeaman, WH Welch, AS Ibrahim… - PLoS …, 2007 - journals.plos.org
Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal
candidiasis. Both of these diseases are characterized by fungal invasion of host cells. …

Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis

C Reed, R Bryant, AS Ibrahim… - Clinical Infectious …, 2008 - academic.oup.com
Background . It has been axiomatic that echinocandins (eg, caspofungin) are ineffective
against mucormycosis. However, on the basis of preclinical data, we recently began treating …

Evidence implicating phospholipase as a virulence factor of Candida albicans

AS Ibrahim, F Mirbod, SG Filler, Y Banno… - Infection and …, 1995 - Am Soc Microbiol
Three different approaches were used to investigate the role of extracellular phospholipases
in the pathogenicity of Candida albicans. First, we compared 11 blood isolates of this yeast …