Background Since the emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
in 2012, the virus had caused a high case fatality rate. The clinical presentation of …

Extracorporeal membrane oxygenation (ECMO) is considered as a supportive treatment
that provides circulatory and ventilatory support and can be thought off as a bridge to organ …

Extracorporeal membrane oxygenation ECMO was widely utilized during the coronavirus
disease COVID-19 pandemic. ECMO provision in Saudi Arabia has shown notable …

Background Type I interferons (IFNs) are essential antiviral cytokines induced upon respiratory
exposure to coronaviruses. Defects in type I IFN signaling can result in severe disease …

The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir
and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir …

Background Whether combined treatment with recombinant interferon beta-1b and lopinavir–ritonavir
reduces mortality among patients hospitalized with Middle East respiratory …

Middle East respiratory syndrome coronavirus (MERS-CoV) is a member of the beta-coronavirus
genus of zoonotic origin that emerged in the Arabian Peninsula and is associated with …

Background SARS-CoV-2 is associated with a severe inflammatory response contributing to
respiratory and systemic manifestations, morbidity, and mortality in patients with coronavirus …

Animal and human data indicate variable effects of interferons in treating coronavirus infections
according to inflammatory status and timing of therapy. In this sub-study of the MIRACLE …

Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with significant
morbidity and mortality due to intense pulmonary inflammation. Enhanced chemokine-…