About 50% of UK patients with β-thalassaemia major die before the age of 35 years, mainly
because conventional iron-chelation therapy is too burdensome for full adherence. Patients …

This report is the first to provide global estimates of birth prevalence for serious birth defects
of genetic or partially genetic origin. The report has 3 major parts. The first is the main body, …

Background Neural tube defects (NTDs) remain an important, preventable cause of mortality
and morbidity. High-income countries have reported large reductions in NTDs associated …

Consanguineous marriage is customary in many societies, but leads to an increased birth
prevalence of infants with severe recessive disorders. It is therefore often proposed that …

As child mortality rates overall are decreasing, non-communicable conditions, such as genetic
disorders, constitute an increasing proportion of child mortality, morbidity and disability. …

To demonstrate a method for using genetic epidemiological data to assess the needs for
equitable and cost-effective services for the treatment and prevention of haemoglobin disorders…

Background The UK Thalassaemia Register records births, deaths and selected clinical data
of patients with thalassaemia who are resident in the UK. A study of survival and causes of …

Thalassemias and the hemoglobinopathies such as Hemoglobins S, C and E, are now a
global problem. They have spread through migration from their native areas in the …

… Bernadette Modell (b.modell{at}pcps.ucl.ac.uk), emeritus professor of community genetics2 …
Correspondence to: B Modell … Modell B …

Neural tube defects (NTDs) are associated with substantial mortality, morbidity, disability,
and psychological and economic costs. Many are preventable with folic acid, and access to …