The design of new chiral catalysts for enantioselective synthesis of all-carbon quaternary
stereogenic centers is a critical and challenging objective in modern chemistry.[1] Such …

Aim To conduct a systematic review and meta‐analysis to determine the risk of cardiovascular
events and all‐cause mortality associated with sulphonylureas ( SUs ) vs other glucose …

Background and aims Low-density lipoprotein cholesterol (LDL-C) is a major contributor to
cardiovascular disease. In the Dyslipidemia International Study II (DYSIS II), we determined …

The first example of an intramolecular asymmetric reductive amination of a dialkyl ketone
with an aliphatic amine has been developed for the synthesis of Suvorexant (MK-4305), a …

A new synthetic route to drug candidate 1, a potent and selective dual orexin antagonist for
the treatment of sleep disorders, has been developed. The key acyclic precursor 10 was …

A novel method is presented using N−N ylides (prepared by in situ amination of a tertiary
amine) for the aziridination of a range of enone systems. The amine may be used sub-…

Background Patients with coronary heart disease (CHD) and survivors of acute coronary
syndrome (ACS) are at very high risk for adverse cardiovascular events. Lowering low-density …

A general procedure for the copper-catalyzed regioselective ring-opening of epoxides with
Grignard reagents is described. The procedure developed provides robust reaction …

A comparative study of chiral Mo- and Ru-based catalysts to promote enantioselective
synthesis of 2,6-disubstituted pyrans and piperidines through asymmetric ring-opening/cross-…

Background As mortality due to cardiovascular disease increases throughout the world,
accurate data on risk factors such as hyperlipidemia are required. This is lacking in the Asia-…