Factor VII is a precursor to a serine protease that is present in mammalian plasma. In its
activated form, it participates in blood coagulation by activating factor X and/or factor IX in the …

Previous studies involving platelet-derived growth factor (PDGF) have been based on the
premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It …

The abilities of bone to remodel, fractures to repair, and bone grafts to incorporate are all
fundamental reflections of the bone remodeling cycle. This process is characterized by the …

Osteopontin is an Arg-Gly-Asp-containing acidic phosphoprotein recently shown to be
upregulated in vascular smooth muscle during rat arterial neointima formation and in human …

The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance
or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was …

We have characterized platelet-derived growth factor (PDGF) C, a novel growth factor
belonging to the PDGF family. PDGF-C is a multidomain protein with the N-terminal region …

Cryptosporidium parasites are leading causes of enteric disease, especially in children. A
prospective survey on the prevalence of cryptosporidiosis in children less than five years of …

Smooth muscle cells (SMC) in rat carotid artery leave the quiescent state and proliferate
after balloon catheter injury, but the signals for mitogenesis are not known. In this study, the …

A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA
cross-linking toxin of the prodrug, ifosfamide. The hypoxia-selective cytotoxicity of several of the …

TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide
mustard currently undergoing clinical evaluation. Here, we describe broad-…