The use of noninvasive methods of monitoring airway inflammation, such as exhaled nitric
oxide (eNO) and induced sputum, has been shown to improve asthma monitoring and …

Background Diagnosing asthma in children represents an important clinical challenge. There
is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-…

The goal of asthma treatment is to obtain clinical control and reduce future risks to the
patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all …

Rationale: Children with severe asthma experience persistent symptoms despite maximal
conventional treatment. Fraction of exhaled nitric oxide (Fe NO ) and sputum eosinophils are …

This review focuses on the methods available for measuring reversible airways obstruction,
bronchial hyperresponsiveness (BHR) and inflammation as hallmarks of asthma, and their …

The purpose of this study was to determine the neurodevelopmental risks in patients with
twin-to-twin transfusion syndrome, a rare but serious complication of monochorionic twin …

Difficult childhood asthma is defined by persistent symptoms despite maximal conventional
therapy. We aimed to establish a safe method of sputum induction for these children and to …

Background It has been suggested that cysteinyl leukotrienes (cysLTs) play an important role
in airway remodeling. Previous reports have indicated that cysLTs augment human airway …

Cough is common in airway disease. We measured cough frequency in children with primary
ciliary dyskinesia (PCD), to determine how accurately families assess this symptom; and to …

Exhaled breath condensate (EBC) has been proposed as a noninvasive tool to study airway
inflammation. The reproducibility of breath condensates was recently questioned. We …