Purpose: We investigated the in vitro and in vivo anti-multiple myeloma activity of
monoclonal antibody (mAb) 1339, a high-affinity fully humanized anti-interleukin 6 mAb (…

The interactions between the leukocyte-specific beta 2-integrins cluster of differentiation (CD)
Ag CD11/CD18 and their ligands, the intercellular adhesion molecules (ICAMs), play …

Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative
due to the high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) …

To identify the epitopes in human interleukin-15 (IL-15) that are responsible for binding to
the interleukin-15 receptor α chain, antibody and receptor mapping by peptide scanning and …

Glioma and renal cell carcinoma (RCC) cells express high affinity interleukin 13 (IL13) binding
sites, but only RCC cell proliferation was inhibited by IL13. Both of these two cell types …

Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however,
therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe …

First described as an interface between blood and tissues, the endothelial cells are now known
to be also involved in haemostasis, inflammatory and immune responses. Recent studies …

This prospective study aimed to assess the incidence of silent hypersensitivity to
Escherichia coli asparaginase in the treatment of acute lymphoblastic leukemia (ALL). Thirty-three …

Gab2 (Grb2-associated binder-2), a member of the IRS (insulin receptor substrate)/Gab family
of adapter proteins, undergoes tyrosine phosphorylation in response to cytokine or growth …

Background Production of high levels of IL-6 is often correlated with resistance to cytotoxics
or ionizing radiations, in cancer cell lines as in various cancer patients. We investigated …