This review discusses the relationship of the efflux pump (EP) system of Gram-negative
bacteria to other antibiotic resistance mechanisms of the bacterium such as quorum sensing, …

Multidrug resistance (MDR) has appeared in response to selective pressures resulting from
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …

Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by
overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or …

Anaerobic bacteria have pivotal roles in the microbiota of humans and they are significant
infectious agents involved in many pathological processes, both in immunocompetent and …

Selenium is an essential trace element that is crucial for cellular antioxidant defense against
reactive oxygen species (ROS). Recently, many selenium-containing compounds have …

Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology.
These compounds are able to effectively inhibit dopamine, histamine, serotonin, …

(HSC-2) and human submandibular gland tumor (HSG) cells was found in the acetone fractions
(A4 and A5) with IC50 ranging from 21 to 59 µg/mL. However, the cytotoxic activity was …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Bacterial plasmids have a major impact on metabolic function. Lactose fermentation of E.
coli or hemolysin B transporter expressed by the plasmids that carry these respective genes …

Helicobacter pylori, two representative Candida species, and human immunodeficiency
virus (HIV). H3, H4 and HE3, which displayed higher tumor-specific cytotoxicity also showed …