Obesity is widely recognized as an epidemic in the Western world; however, the impact of
obesity on the skin has received minimal attention. The purpose of this article is to highlight the …

The “acid mantle” is a topic not only of historical interest, but also of clinical significance and
has recently been linked to vital stratum corneum function. Despite compelling basic science …

The neurobiology of itch, which is formally known as pruritus, and its interaction with pain
have been illustrated by the complexity of specific mediators, itch-related neuronal pathways …

Key Clinical Points Chronic Pruritus Chronic pruritus (itching that persists for more than 6
weeks) may be caused by inflammatory skin diseases, systemic diseases, neuropathic …

Acta Derm Venereol 87 tent definitions of clinical terms and classifications of pruritus befitting
the enormity and complexity of this clinical problem. This is the first version of a clinical …

Background Abrocitinib, an oral selective Janus kinase 1 inhibitor, was effective and well
tolerated in adults with moderate-to-severe atopic dermatitis in a phase 2b trial. We aimed to …

Itch is a common skin sensation, with substantial effects on behaviour. Neurophysiological
research has permitted accurate definition of neural pathways of itch, and has confirmed the …

Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with these …

Although circadian rhythms have been described formany human functions, there are minimal
data on circadian rhythms related to skin physiology. This study investigated the circadian …

Background Prurigo nodularis is a chronic, debilitating, and severely pruritic neuroimmunologic
skin disease. Nemolizumab, an interleukin-31 receptor alpha antagonist, down-…