Endothelial dysfunction in Covid-19 infection

HM Otifi, BK Adiga - The American journal of the medical sciences, 2022 - Elsevier
COVID-19 is an evolving systemic inflammatory pandemic disease, predominantly affecting
the respiratory system. Associated cardiovascular comorbid conditions result in severe to …

[HTML][HTML] Evaluation of the effect of COVID-19 mandated shift to virtual teaching on medical students' performance at King Khalid University, Abha

HM Otifi, HM Hassan, MO Andarawi - Journal of Taibah University Medical …, 2023 - Elsevier
Objectives The rapid spread of the COVID-19 pandemic required populations in most parts
of the world to take drastic precautions. Face-to-face teachings were suspended, and the …

[HTML][HTML] Unraveling Extremely Damaging IRAK4 Variants and Their Potential Implications for IRAK4 Inhibitor Efficacy

MY Behairy, RA Eid, HM Otifi, HM Mohammed… - Journal of Personalized …, 2023 - mdpi.com
Interleukin-1-receptor-associated kinase 4 (IRAK4) possesses a crucial function in the toll-like
receptor (TLR) signaling pathway, and the dysfunction of this molecule could lead to …

[HTML][HTML] Computational docking and in vitro analysis identifies novel arylidene analogue FPMXY-14 against renal cancer cells by attenuating Akt

HM Otifi, M Alshyarba, M Al Fayi, AA Dera… - Oncology …, 2021 - ncbi.nlm.nih.gov
Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims
to screen FPMXY-14 (novel arylidene analogue) for Akt inhibition by computational and in …

[HTML][HTML] A Comprehensive Pan-Cancer Analysis Identifies CEP55 as a Potential Oncogene and Novel Therapeutic Target

…, SM Al-Qahtani, HM Otifi, A Asiri, HM Hassan… - Diagnostics, 2023 - mdpi.com
Emerging research findings have shown that a centrosomal protein (CEP55) is a potential
oncogene in numerous human malignancies. Nevertheless, no pan-cancer analysis has been …

[HTML][HTML] Clinicopathological features and prevalence of prostate cancer in Aseer, Saudi Arabia

HM Otifi, OMS Abdul-Wahab, MH Al-Shyarba… - Saudi Medical …, 2022 - ncbi.nlm.nih.gov
Objectives: To determine the prevalence and characterize prostate cancer (PC) cases in
Aseer, Saudi Arabia. Methods: This study involved 883 patients who consulted physicians in …

In silico high throughput screening and in vitro validation of a novel Raf/Mek dual inhibitor against colorectal carcinoma

HM Otifi - Biologia, 2022 - Springer
Activation of the Raf/Mek pathway is critical in colorectal cancers (CRC). Several activating
mutations have been reported in CRC, where activation of B-Raf by valine to glutamate at …

Deciphering Immune Complexity: Single-Cell Insights into Autoimmune Myocarditis Progression

…, E Fayad, RA Eid, G Alsharif, MA Alshehri, HM Otifi… - bioRxiv, 2024 - biorxiv.org
Autoimmune myocarditis is a complex inflammatory response in the heart caused by abnormal
immune system activity. We used modern single-cell technologies to analyze the complex …

Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling

M Al Fayi, H Otifi, M Alshyarba, AA Dera… - Journal of Drug …, 2020 - Taylor & Francis
This study evaluates the protective effects of Thymoquinone (Tq) and Curcumin (Cur) in models
of cisplatin-induced renal toxicity. Proliferation studies were carried out in HEK-293 cells. …

Thymoquinone inhibits IL‐7‐induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF …

M Alshyarba, H Otifi, M Al Fayi, AA Dera… - Biotechnology and …, 2021 - Wiley Online Library
Interleukin (IL)‐7 acts via the IL‐7 receptor in metastatic tumor progression in prostate cancer
(PC). The current study aimed to evaluate thymoquinone (Tq), an active constituent from …