[HTML][HTML] Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods
…, Y Xu, M Li, X Li, M Zheng, L Chen, H Li - … Pharmaceutica Sinica B, 2020 - Elsevier
SARS-CoV-2 has caused tens of thousands of infections and more than one thousand deaths.
There are currently no registered therapies for treating coronavirus infections. Because of …
There are currently no registered therapies for treating coronavirus infections. Because of …
[HTML][HTML] Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
H Li, J Chen, W Wu, T Fagaly, L Zhou, W Yuan… - Cell, 1999 - cell.com
The olfactory bulb plays a central role in olfactory information processing through its connections
with both peripheral and cortical structures. Axons projecting from the olfactory bulb to …
with both peripheral and cortical structures. Axons projecting from the olfactory bulb to …
Solution NMR studies of the Aβ (1− 40) and Aβ (1− 42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation
L Hou, H Shao, Y Zhang, H Li, NK Menon… - Journal of the …, 2004 - ACS Publications
The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation
of the 40-residue Aβ(1−40) and 42-residue Aβ(1−42) peptides into amyloid plaques. The …
of the 40-residue Aβ(1−40) and 42-residue Aβ(1−42) peptides into amyloid plaques. The …
[HTML][HTML] A chromosome conformation capture ordered sequence of the barley genome
Cereal grasses of the Triticeae tribe have been the major food source in temperate regions
since the dawn of agriculture. Their large genomes are characterized by a high content of …
since the dawn of agriculture. Their large genomes are characterized by a high content of …
Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and …
H Li, V Papadopoulos - Endocrinology, 1998 - academic.oup.com
In steroid-synthesizing cells, like the MA-10 mouse tumor Leydig cells, the peripheral-type
benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein involved in the …
benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein involved in the …
[HTML][HTML] Biological activities of polyphenols from grapes
EQ Xia, GF Deng, YJ Guo, HB Li - International journal of molecular …, 2010 - mdpi.com
The dietary consumption of grape and its products is associated with a lower incidence of
degenerative diseases such as cardiovascular disease and certain types of cancers. Most …
degenerative diseases such as cardiovascular disease and certain types of cancers. Most …
[HTML][HTML] Ferroptosis: mechanisms and links with diseases
H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the …
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the …
A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates
GR Chichili, L Huang, H Li, S Burke, L He… - Science translational …, 2015 - science.org
Current therapies for acute myeloid leukemia (AML) are largely ineffective, and AML
patients may benefit from targeted immunotherapy approaches. MGD006 is a bispecific …
patients may benefit from targeted immunotherapy approaches. MGD006 is a bispecific …
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways
N 6 -methyladenosine (m 6 A) is the most common and abundant messenger RNA
modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark 1 , 2 . In vitro data have …
modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark 1 , 2 . In vitro data have …
DNA nanotechnology-enabled drug delivery systems
Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical
areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA …
areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA …