Exhaled nitric oxide (Fe no ) has been proposed as a noninvasive marker of airway inflammation
in asthma, and may reflect airway eosinophilia. We examined the relationship between …

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
airway inflammation that is greater in patients with advanced disease. We asked whether there …

Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and acute …

We have investigated the ability of dexamethasone to regulate interleukin-1β (IL-1β)-induced
gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity…

… Barnes, Ian M. Adcock; Histone deacetylase 2–mediated deacetylation of the glucocorticoid
receptor enables NF-κB suppression . J Exp Med 23 January 2006; 203 (1): 7–13. doi: https://…

The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown,
but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic exposure…

Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease
of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. …